#1110337 ITP: rfdiffusion -- protein structure generation with or without conditional information

Package:
wnpp
Source:
wnpp
Submitter:
Steffen Moeller
Date:
2025-11-29 16:58:29 UTC
Severity:
normal
#1110337#5
Date:
2025-08-03 12:49:46 UTC
From:
To:
* Package name    : rfdiffusion
  Version         : 1.1.0
* URL             : https://github.com/RosettaCommons/RFdiffusion
* License         : BSD
  Programming Lang: Python
  Description     : protein structure generation with or without conditional information

RFdiffusion is an open source method for structure generation, with or without conditional information (a motif, target etc). It can perform a whole range of protein design challenges as we have outlined in the RFdiffusion paper.

Things Diffusion can do

 * Motif Scaffolding
 * Unconditional protein generation
 * Symmetric unconditional generation (cyclic, dihedral and tetrahedral symmetries currently implemented, more coming!)
 * Symmetric motif scaffolding
 * Binder design
 * Design diversification ("partial diffusion", sampling around a design)