Hi! While rebuilding the python related packages against the Python 3.15rc1 version we found that rdkit fails to build from source not only for 3.15 but also for 3.14 [1]. Error: testDistGeomHelpers: src/catch2/../catch2/internal/catch_output_redirect.hpp:40: void Catch::OutputRedirect::activate(): Assertion !m_redirectActive && "redirect is already active"' failed. This is because catch2 is not thread safe till release 3.12, but currently we have 3.7 in Debian, so the tests that depend on thread safety need workarounds. It's likely that this only started happening now, due to the new gcc version. I applied the fix in the sandbox [2] to be able to build the packages that depend on rdkit and it has built successfully, please consider applying the patch to get rdkit to build successfully. Happy hacking, [1]: https://debusine.debian.net/debian/r-python-python3.15/artifact/4587746/ [2]: https://debusine.debian.net/debian/r-python-python3.15/