Hi! While rebuilding the python related packages against the Python 3.15rc2 version we found that rdkit only builds against the default Python version. This is a problem because it doesn't build the module for Python 3.15, making packages that depend on it also unable to build for Python 3.15 (for example, mdanse). To fix this, I've made a change that makes rdkit build against all supported Python versions. I'm attaching a debdiff with this and the changes made for #1146588. I've applied the fix in the sandbox [1] to verify that both rdkit and the packages that depend on it build successfully. Please consider applying the patch to support the upcoming 3.15 version. Setting the severity to important for now. Once Python 3.15 is released, it will be added to python3-defaults and this bug will become release critical. Happy hacking, [1]: https://debusine.debian.net/debian/r-python-python3.15/