In /usr/share/doc/sa-exim/README.gz the readme correctly proposed to add some exclusions/overrides that prevent spamassassin run against locally generated or 'trusted' senders. I was caming from an old, mosly sarge based setup, and i moved from the header-type exclusion to acl variable exclusion, but found that what proposed on file above, section: EXIM4 INTEGRATION / NOT SCANNING YOUR OWN MAILS does not work very well, scan every local generated email. After some exim documentation reeding (ok, and a bit of google ;) i've added in main section of exim4.conf: acl_not_smtp = acl_check_local_mail and on acl section: acl_check_local_mail: warn set acl_m0 = do-not-scan accept With this setup again sa-exim stop to check ocal submitted email. Also this remove the flooding of: Can only handle IPv4 addresses; skipping greylisting call for message from spamd, because seems that the only source of ipv6 traffic, at least in italy, are localhost. ;-) Many thanks.